Tim Sale is the star of this book. His Hulk feels magical. He's emotional, without being cartoony. Vulnerable but always intimidating. This is a real feat in comics where portraying strength in a hero/villain is the go to choice. Emotionality is not a strength for many comic book artists. Tim Sale is the absolute peak for me, specially with his 'monsters'.
Jeff Loeb is not great a writing women. I have more complaints about this in Spider-Man: Blue, but his Betty Ross isn't great. Her appearance is usually arbitrary and her emotional life felt fairly empty. She loves Bruce... where is Bruce...oh my god, Bruce... is he dead? There are version of Betty where she is scientist as well. Not this version. I believe these are Loeb and Sale's version of Hulk's classical origin, so better is just a girlfriend, with no life outside her father and her lover.
That was the low point of the series for me. The high point was this one particular moment with Hulk and a small animal. Absolutely devastating and, yet, perfect. All you need to know to understand the hulk in just a few panels. That was excellent comic book writing. I'm crying right now just thinking about it. (Loeb and Sale have done this for me before, with Dark Victory. The power of good pacing and evocative art. There is not substitute for it.)