Takeaways : I can't fix your genetic predisposition to dying from the 4 horseman (CV disease, dementia, cancer, and metabolic syndrome), but there's plenty of modifiable risk factors which I can control. I need to do this with the 4 types of exercise he outlines (zone 2, zone 5, strength, balance/movement), socializing, sleep, and optimizing atherosclerotic cardiovascular disease through medical tests and meds if needed. Diet appears to either be not as important or too difficult to study accurately, and so I shouldn't fixate on one of the major food religions. Instead, I need to get a lot of protein, avoid processed foods, get a good mix of fats, eat plants, and avoid alcohol and drugs. Inspiring book! Also I noted a 3 act structure which led to some unexpected catharsis at the end. In the first few chapters, he demonstrates preternatural focus, drive, and intelligence; a respectable yet not threatening man. He gradually introduces hints of interpersonal issues (his wife, his residency attendings) interspersed between his meticulously researched advice and anecdotes revealing his demanding, almost superhuman daily routine. I certainly began to wonder what the catch was, and I wondered if he was a workaholic, and if so, what drove him to be that way? Temperament, conscientiousness-bordering-on-neuroticism, and parental pressure, like so many medical students? Well, let me just say he does eventually reveal his Achilles heel, and in a self-aware, intimate way. An excellent narrative weaved into the more straightforward stuff